Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

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Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

BACKGROUND Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine kinase that plays an important role in cancer tumorigenesis and progression. We investigated the role of the GSK-3β inhibitor AZD1080 in ovarian cancer cell lines. METHODS A2780 and OVCAR3 ovarian cancer cell lines were exposed to AZD1080, after which cell proliferation, cell cycle, invasion, and migration a...

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ژورنال

عنوان ژورنال: Drug Design, Development and Therapy

سال: 2016

ISSN: 1177-8881

DOI: 10.2147/dddt.s102506